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Clinical acupuncture research in the West
Xianze Meng, Shifen Xu, Lixing Lao
《医学前沿（英文）》 2011年 第5卷 第2期 页码 134-140 doi: 10.1007/s11684-011-0135-9
关键词： acupuncture clinical research research methodology the West
Construction of a shared system-based real-world clinical research system
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《医学前沿（英文）》 2014年 第8卷 第3期 页码 382-388 doi: 10.1007/s11684-014-0368-5
Hubei Provincial Hospital of Traditional Chinese Medicine established research outpatient clinics to contribute to the major disease-entity research conducted by the National Traditional Chinese Medicine Clinical Research Base and to the construction of the National Traditional Chinese Medicine Treatment and Clinical Research Information Sharing System. With a view of developing a “real-world traditional Chinese medicine clinical research paradigm,” these clinics explored the mode of constructing research outpatient clinics from the aspects of clinical research, health management, and characteristics diagnosis and treatment.
关键词： clinical research shared system real world research outpatient clinic research hospital
Clinical research of traditional Chinese medicine in big data era
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《医学前沿（英文）》 2014年 第8卷 第3期 页码 321-327 doi: 10.1007/s11684-014-0370-y
With the advent of big data era, our thinking, technology and methodology are being transformed. Data-intensive scientific discovery based on big data, named “The Fourth Paradigm,” has become a new paradigm of scientific research. Along with the development and application of the Internet information technology in the field of healthcare, individual health records, clinical data of diagnosis and treatment, and genomic data have been accumulated dramatically, which generates big data in medical field for clinical research and assessment. With the support of big data, the defects and weakness may be overcome in the methodology of the conventional clinical evaluation based on sampling. Our research target shifts from the “causality inference” to “correlativity analysis.” This not only facilitates the evaluation of individualized treatment, disease prediction, prevention and prognosis, but also is suitable for the practice of preventive healthcare and symptom pattern differentiation for treatment in terms of traditional Chinese medicine (TCM), and for the post-marketing evaluation of Chinese patent medicines. To conduct clinical studies involved in big data in TCM domain, top level design is needed and should be performed orderly. The fundamental construction and innovation studies should be strengthened in the sections of data platform creation, data analysis technology and big-data professionals fostering and training.
关键词： big data traditional Chinese medicine clinical evaluation evidence based medicine
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《医学前沿（英文）》 2014年 第8卷 第3期 页码 300-309 doi: 10.1007/s11684-014-0357-8
The current modes of experience inheritance from famous specialists in traditional Chinese medicine (TCM) include master and disciple, literature review, clinical-epidemiology-based clinical research observation, and analysis and data mining via computer and database technologies. Each mode has its advantages and disadvantages. However, a scientific and instructive experience inheritance mode has not been developed. The advent of the big data era as well as the formation and practice accumulation of the TCM clinical research paradigm in the real world have provided new perspectives, techniques, and methods for inheriting experience from famous TCM specialists. Through continuous exploration and practice, the research group proposes the innovation research mode based on the real-world TCM clinical research paradigm, which involves the inheritance and innovation of the existing modes. This mode is formulated in line with its own development regularity of TCM and is expected to become the main mode of experience inheritance in the clinical field.
关键词： traditional Chinese medicine (TCM) real world clinical research paradigm famous specialist experience inheritance
Scientific computation of big data in real-world clinical research
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《医学前沿（英文）》 2014年 第8卷 第3期 页码 310-315 doi: 10.1007/s11684-014-0358-7
The advent of the big data era creates both opportunities and challenges for traditional Chinese medicine (TCM). This study describes the origin, concept, connotation, and value of studies regarding the scientific computation of TCM. It also discusses the integration of science, technology, and medicine under the guidance of the paradigm of real-world, clinical scientific research. TCM clinical diagnosis, treatment, and knowledge were traditionally limited to literature and sensation levels; however, primary methods are used to convert them into statistics, such as the methods of feature subset optimizing, multi-label learning, and complex networks based on complexity, intelligence, data, and computing sciences. Furthermore, these methods are applied in the modeling and analysis of the various complex relationships in individualized clinical diagnosis and treatment, as well as in decision-making related to such diagnosis and treatment. Thus, these methods strongly support the real-world clinical research paradigm of TCM.
关键词： big data real world clinical research Chinese medicine medical computing
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《医学前沿（英文）》 2016年 第10卷 第1期 页码 104-110 doi: 10.1007/s11684-016-0432-4
Advances in next-generation sequencing and bioinformatics have begun to reveal the complex genetic landscape in human cancer genomes, including oral squamous cell carcinoma (OSCC). Sophisticated preclinical models that fully represent intra- and inter-tumoral heterogeneity are required to understand the molecular diversity of cancer and achieve the goal of personalized therapies. Patient-derived xenograft (PDX) models generated from human tumor samples that can retain the histological and genetic features of their donor tumors have been shown to be the preferred preclinical tool in translational cancer research compared with other conventional preclinical models. Specifically, genetically well-defined PDX models can be applied to accelerate targeted antitumor drug development and biomarker discovery. Recently, we have successfully established and characterized an OSCC PDX panel as part of our tumor bio-bank for translational cancer research. In this paper, we discuss the establishment, characterization, and preclinical applications of the PDX models. In particular, we focus on the classification and applications of the PDX models based on validated annotations, including clinicopathological features, genomic profiles, and pharmacological testing information. We also explore the translational value of this well-annotated PDX panel in the development of co-clinical trials for patient stratification and treatment optimization in the near future. Although various limitations still exist, this preclinical approach should be further tested and improved.
关键词： patient-derived xenograft models personalized medicine co-clinical trial patient stratification oral squamous cell carcinoma
Overcoming the challenges of conducting translational research in cell therapy
Sowmya Viswanathan, Armand Keating
《医学前沿（英文）》 2011年 第5卷 第4期 页码 333-335 doi: 10.1007/s11684-011-0166-2
关键词： stem cells clinical trials funding animal models standardization common definitions
Basic consideration of research strategies for head and neck cancer
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《医学前沿（英文）》 2012年 第6卷 第4期 页码 339-353 doi: 10.1007/s11684-012-0213-7
Head and neck cancer (HNC) consists of a group of malignancies affecting closely related anatomical regions of the upper aerodigestive tract (UADT), including the oral cavity, salivary glands, upper and lower jaw bones and facial skin; the nasal cavity, paranasal sinuses, pharynx, larynx and thyroid gland (although the latter is often excluded and considered as part of endocrine neoplasms). Of these, 90% of HNCs are histologically squamous cell carcinomas originating from the mucosal lining. These malignancies are strongly associated with certain environmental and life-style risk factors, principally tobacco in both smoked and smokeless forms, excessive alcohol consumption, diets poor in antioxidants and essential micronutrients, UV light, chemicals used in certain workplaces, and viruses, principally certain strains of human papillomavirus (HPV) and Epstein-Barr virus (EBV). These cancers are frequently aggressive in their biological behaviour with local invasion and metastasis to lymph nodes in the neck. Since most patients are already at late stages of disease at the time of diagnosis, the desirable practice of early diagnosis (first sign of the malignant lesion at an initial stage ) and early treatment, a critical priority to save lives and retain quality of life, is difficult to implement. Thus, primary prevention has been set as a key goal. This article aims to reinforce the basic knowledge of aetiology, key risk factors related to the development of head and neck cancer, basic features of clinical appearance of this group of cancers, and strategies for prevention and early detection. We also suggest basic research strategies on the basis of current knowledge, which should ultimately lead to the improvement of clinical management.
关键词： clinical management head and neck cancer prevention and early detection research strategies risk factors
Clinical data quality problems and countermeasure for real world study
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《医学前沿（英文）》 2014年 第8卷 第3期 页码 352-357 doi: 10.1007/s11684-014-0351-1
Real world study (RWS) has become a hotspot for clinical research. Data quality plays a vital role in research achievement and other clinical research fields. In this paper, the common quality problems in the RWS of traditional Chinese medicine are discussed, and a countermeasure is proposed.
关键词： real world study traditional Chinese medicine clinical and research information sharing system data quality problem data quality control
Ontological reconstruction of the clinical terminology of traditional Chinese medicine
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《医学前沿（英文）》 2014年 第8卷 第3期 页码 358-361 doi: 10.1007/s11684-014-0348-9
This study proposes the ontological reconstruction of the current clinical terminology of traditional Chinese medicine (TCM). It also provides an overview of preliminary work related to the said reconstruction, including the ontology-based analysis of TCM clinical terminology. We conclude that the ontological reconstruction of TCM clinical terminology provides a proper translation from the idealized organizational model to real-world implementation and to a formalized, shared, and knowledge-based framework.
关键词： ontology traditional Chinese medicine clinical terminology
《医学前沿（英文）》 2023年 第17卷 第3期 页码 527-533 doi: 10.1007/s11684-022-0967-5
关键词： orthotopic heart transplant tricuspid regurgitation clinical impact biatrial heart transplantation
Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment
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《医学前沿（英文）》 2017年 第11卷 第3期 页码 340-348 doi: 10.1007/s11684-017-0570-3
In light of the rapid increase in the number of obesity incidences worldwide, obesity has become an independent risk factor for chronic kidney disease. Obesity-related glomerulopathy (ORG) is characterized by glomerulomegaly in the presence or absence of focal and segmental glomerulosclerosis lesions. IgM and complement 3 (C3) nonspecifically deposit in lesions without immune-complex-type deposits during ORG immunofluorescence. ORG-associated glomerulomegaly and focal and segmental glomerulosclerosis can superimpose on other renal pathologies. The mechanisms under ORG are complex, especially hemodynamic changes, inflammation, oxidative stress, apoptosis, and reduced functioning nephrons. These mechanisms synergize with obesity to induce end-stage renal disease. A slow increase of subnephrotic proteinuria (<3.5 g/d) is the most common clinical manifestation of ORG. Several treatment methods for ORG have been developed. Of these methods, renin–angiotensin–aldosterone system blockade and weight loss are proven effective. Targeting mitochondria may offer a novel strategy for ORG therapy. Nevertheless, more research is needed to further understand ORG.
关键词： obesity-related glomerulopathy pathogenesis pathologic clinical characteristics
Coronavirus disease 2019 (COVID-19): a clinical update
Min Zhou, Xinxin Zhang, Jieming Qu
《医学前沿（英文）》 2020年 第14卷 第2期 页码 126-135 doi: 10.1007/s11684-020-0767-8
关键词： coronavirus disease 2019 epidemiology pathology radiology clinical characteristics treatment
Hypertension in patients with CKD in China: clinical characteristics and management
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《医学前沿（英文）》 2017年 第11卷 第3期 页码 307-309 doi: 10.1007/s11684-017-0578-8
《医学前沿（英文）》 2022年 第16卷 第4期 页码 551-573 doi: 10.1007/s11684-022-0928-z
关键词： HCC bone osteotropism clinical basic researches advances
标题 作者 时间 类型 操作
Experience inheritance from famous specialists based on real-world clinical research paradigm of traditional
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期刊论文
Patient-derived xenograft platform of OSCC: a renewable human bio-bank for preclinical cancer researchand a new co-clinical model for treatment optimization
null
期刊论文
Overcoming the challenges of conducting translational research in cell therapy
Sowmya Viswanathan, Armand Keating
期刊论文
The clinical impact of tricuspid regurgitation in patients with a biatrial orthotopic heart transplant
期刊论文
Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment
null
期刊论文
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